Ribosomes and Protein Synthesis

Art Connections

Figure Many antibiotics inhibit bacterial protein synthesis. For example, tetracycline blocks the A site on the bacterial ribosome, and chloramphenicol blocks peptidyl transfer. What specific effect would you expect each of these antibiotics to have on protein synthesis?

Tetracycline would directly affect:

  1. tRNA binding to the ribosome
  2. ribosome assembly
  3. growth of the protein chain

Chloramphenicol would directly affect

  1. tRNA binding to the ribosome
  2. ribosome assembly
  3. growth of the protein chain

Hint:

Figure Tetracycline: a; Chloramphenicol: c.