Biology 2e is designed to cover the scope and sequence requirements of a typical two-semester biology course for science majors. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology includes rich features that engage students in scientific inquiry, highlight careers in the biological sciences, and offer everyday applications. The book also includes various types of practice and homework questions that help students understand—and apply—key concepts. The 2nd edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Art and illustrations have been substantially improved, and the textbook features additional assessments and related resources.

By the end of this section, you will be able to do the following:

Explain the need for nitrogen fixation and how it is accomplished
Describe the beneficial effects of bacteria that colonize our skin and digestive tracts
Identify prokaryotes used during the processing of food
Describe the use of prokaryotes in bioremediation

By the end of this section, you will be able to do the following:

Explain pharmacogenomics
Define polygenic

By the end of this section, you will be able to do the following:

Describe gel electrophoresis
Explain molecular and reproductive cloning
Describe biotechnology uses in medicine and agriculture

By the end of this section, you will be able to do the following:

Explain systems biology
Describe a proteome
Define protein signature

By the end of this section, you will be able to do the following:

Define genomics
Describe genetic and physical maps
Describe genomic mapping methods

By the end of this section, you will be able to do the following:

Describe three types of sequencing
Define whole-genome sequencing

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

This course will introduce the student to the major concepts of biotechnology. The student will discuss genetic engineering of plants and animals and the current major medical, environmental, and agricultural applications of each. There are also a variety of topics that this course will cover after ranging from nanobiotechnology to environmental biotechnology. Upon successful completion of this course, the student will be able to: identify and describe the fields of biotechnology; compare and contrast forward and reverse genetics and the way they influence biodiversity; compare and contrast systemic studies of the genome, transcriptome, and proteome; explain how genome projects are performed, and discuss the completion and the information processing in these projects; describe and explain the principles of existing gene therapies; design strategies that support genetic counseling; explain and analyze DNA fingerprints, and compare DNA fingerprints to non-DNA biometrics; describe and compare bioremediation technologies in air, water, and soil; design strategies for generating genetically modified organisms, and discuss ethical concerns; discuss emerging fields in biotechnology. (Biology 403)

Given the broad definition of biotechnology applications and products, it is easy to see how there is enormous overlap within the fields of cellular biology, microbiology, chemistry, and biomedical engineering. It is the goal of this textbook to provide foundational knowledge to begin building your biotechnology toolkit and enter an exciting career of making a difference through biotechnology.

This textbook first explores the fundamentals of laboratory science and biotechnology. Unit 1 begins with a dive into the foundation of biology and chemistry by asking what is life and what are the molecules of life? The end of the unit offers a primer into laboratory science; preparing solutions and operating basic lab equipment. Unit 2 brings readers through a vital tool of biomanufacturing, understanding the growth and control of microbes. Many biotechnology products are made by harnessing the work of microbes, and this unit explores this invisible and intriguing world of microorganisms. The final unit, molecular biotechnology, offers a more in-depth look at how biological molecules such as DNA and protein are manipulated into creating useful products.

Table of Contents
1 Unit 1. The Foundations of Biotechnology

Chapter 1. The Study of Life
Chapter 2. The Building Blocks of Life
Chapter 3. What is Biotechnology?
Chapter 4. Biotechnician Tools: Measurements & Uncertainty
Chapter 5. Biotechnician Tools: Preparing Solutions
Chapter 6. Biotechnician Tools: Basic Laboratory Equipment
2 Unit 2. Introduction to Biomanufacturing

Chapter 7. Cell Structure and Function
Chapter 8. Microbes
Chapter 9. Microbial Techniques
Chapter 10. Microbial Growth
Chapter 11. Control of Microbial Growth
3 Unit 3. Molecular Biotechnology

Chapter 12. Nucleic Acid Structure & Function
Chapter 13. Protein Structure and Function
Chapter 14. Laboratory Techniques: Nucleic Acids and Proteins
Chapter 15. Viruses, Vaccines, and the Immune System
Chapter 16. Immunochemistry

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering.

This course is the first in a three-course sequence that introduces biology in preparation for advanced study in areas of biological science such as medicine, dentistry, cell biology, microbiology, or veterinary medicine. Biol& 211 introduces students to cellular structure and function. Major topics studied include: energy capture and utilization, cellular reproduction, inheritance, genetic mutation, protein synthesis, gene expression, and biotechnology.

With the Genetics Tool, you can: * Cross two organisms * Self-cross one organism * Create mutant versions of one organismWith the Biochemistry Tool, you can: * Look at the structures and colors of the pigment proteins found in one organism * Design proteins and observe their shapes and colors * Compare the amino acid sequences of different pigment proteinsWith the Molecular Biology Tool, you can: * Look at the DNA, mRNA and protein sequences of pigment protein genes * Design genes and observe the colors of the resulting proteins by editing the top DNA strand * Compare the DNA sequences of different pigment protein genes * Create new organisms by specifying their DNA sequences

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.