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Antibiotics, Toxins, and Protein Engineering, Spring 2007
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CC BY-NC-SA
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The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Subject:
Biology
Natural Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Sassanfar, Mandana
Date Added:
01/01/2007
Biological Chemistry II, Spring 2016
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CC BY-NC-SA
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More advanced treatment of biochemical mechanisms that underlie biological processes. Emphasis on experimental methods used to unravel these processes, and how these processes fit into the cellular context and coordinate regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and structure and function of nucleic acids.

Subject:
Biology
Chemistry
Education
Natural Science
Physical Science
Material Type:
Activity/Lab
Assessment
Diagram/Illustration
Full Course
Homework/Assignment
Lecture Notes
Syllabus
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Stubbe, JoAnne
Stubbe, Joanne
Ting, Alice
Date Added:
01/01/2004
Biology 2e
Unrestricted Use
CC BY
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Biology 2e is designed to cover the scope and sequence requirements of a typical two-semester biology course for science majors. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology includes rich features that engage students in scientific inquiry, highlight careers in the biological sciences, and offer everyday applications. The book also includes various types of practice and homework questions that help students understand—and apply—key concepts. The 2nd edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Art and illustrations have been substantially improved, and the textbook features additional assessments and related resources.

Subject:
Biology
Material Type:
Full Course
Provider:
Rice University
Provider Set:
OpenStax College
Date Added:
03/07/2018
Cell Biology: Structure and Functions of the Nucleus, Spring 2010
Conditional Remix & Share Permitted
CC BY-NC-SA
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The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Subject:
Biology
Natural Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Sharp, Phillip
Young, Richard
Date Added:
01/01/2010
Experimental Molecular Biology: Biotechnology II, Spring 2005
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Laboratory uses yeast as an experimental system to study fundamental problems in understanding cell cycle and chromosome segregation. Experimental work combines genetic approaches with the tools of molecular and cell biology to identify and characterize novel genes that act on these processes. Instruction and practice in written and oral communication provided.

Subject:
Biology
Natural Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Date Added:
01/01/2005
Genetics, Fall 2004
Conditional Remix & Share Permitted
CC BY-NC-SA
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The principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes and genomes. Biological variation resulting from recombination, mutation, and selection. Population genetics. Use of genetic methods to analyze protein function, gene regulation and inherited disease.

Subject:
Biology
Education
Genetics
Natural Science
Material Type:
Activity/Lab
Assessment
Diagram/Illustration
Full Course
Homework/Assignment
Lecture Notes
Student Guide
Syllabus
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Fink, Gerald
Kaiser, Chris
Mischke, Michelle
Samson, Leona
Date Added:
01/01/2004
Introduction to Biology, Fall 2004
Conditional Remix & Share Permitted
CC BY-NC-SA
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The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

Subject:
Biology
Natural Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Date Added:
01/01/2004
RNA Interference: A New Tool for Genetic Analysis and Therapeutics, Fall 2004
Conditional Remix & Share Permitted
CC BY-NC-SA
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Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has already changed the way biomedical research is done and that may even prove useful for genetic interventions in a clinical context. In this course, students learn how RNAi was discovered, how it works, and what its physiological relevance might be. How RNAi can be harnessed to modulate gene expression and perform genetic screens, both in cells and in various organisms is also covered. Finally, this course examines the first attempts to use RNAi for the treatment of models of human diseases in experimental animals.

Subject:
Biology
Natural Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Kissler, Stephan
Ventura, Andrea
Date Added:
01/01/2004