Biology 2e is designed to cover the scope and sequence requirements of a typical two-semester biology course for science majors. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology includes rich features that engage students in scientific inquiry, highlight careers in the biological sciences, and offer everyday applications. The book also includes various types of practice and homework questions that help students understand—and apply—key concepts. The 2nd edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Art and illustrations have been substantially improved, and the textbook features additional assessments and related resources.

By the end of this section, you will be able to do the following:

Explain adaptive immunity
Compare and contrast adaptive and innate immunity
Describe cell-mediated immune response and humoral immune response
Describe immune tolerance

By the end of this section, you will be able to do the following:

Explain cross-reactivity
Describe the structure and function of antibodies
Discuss antibody production

By the end of this section, you will be able to do the following:

Describe hypersensitivity
Define autoimmunity

By the end of this section, you will be able to do the following:

Describe physical and chemical immune barriers
Explain immediate and induced innate immune responses
Discuss natural killer cells
Describe major histocompatibility class I molecules
Summarize how the proteins in a complement system function to destroy extracellular pathogens

Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics.

This course is an advanced undergraduate seminar based upon discussions and critical analysis of primary literature in the field of immunology. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease specific immune evasion and the mechanisms used by pathogens to prevail over their host's immune systems are discussed. What these host-pathogen interactions reveal about the normal function of the immune system and about basic cell biological processes, such as protein maturation and degradation, are also considered.

This sequence explores the elements of innate and acquired immune defense mecahnisms, the cells involved, their development and maturation, and biomolecular cellular communication mechanisms required to successfully fight off infection.

This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.