Study of the morphology, physiology and immunogenicity of disease-causing bacteria; methods of isolation, identification and control of pathogenic bacteria and diseases.
Course Description: In this course, we will examine how the immune system …
Course Description: In this course, we will examine how the immune system acts to destroy pathogenic invaders while tolerating colonization by necessary commensal bacteria. As a counterpoint, we will also explore sophisticated strategies that help some bacteria evade our immune system. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Learning Objectives in this unit: Distinguish between signs and symptoms of disease …
Learning Objectives in this unit:
Distinguish between signs and symptoms of disease Explain the difference between a communicable disease and a noncommunicable disease Compare different types of infectious diseases, including iatrogenic, nosocomial, and zoonotic diseases Identify and describe the stages of an acute infectious disease in terms of number of pathogens present and severity of signs and symptoms Summarize Koch’s postulates and molecular Koch’s postulates, respectively, and explain their significance and limitations Explain the concept of pathogenicity (virulence) in terms of infectious and lethal dose Distinguish between primary and opportunistic pathogens and identify specific examples of each Summarize the stages of pathogenesis Explain the roles of portals of entry and exit in the transmission of disease and identify specific examples of these portals Explain how virulence factors contribute to signs and symptoms of infectious disease Differentiate between endotoxins and exotoxins Describe and differentiate between various types of exotoxins Describe the mechanisms viruses use for adhesion and antigenic variation Describe virulence factors unique to fungi and parasites Compare virulence factors of fungi and bacteria Explain the difference between protozoan parasites and helminths Describe how helminths evade the host immune system
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