Students will learn about the use of biomaterials to create advanced diagnostic tools for detection of infectious and chronic diseases, restore insulin production to supplement lost pancreatic function in diabetes, provide cells with appropriate physical, mechanical, and biochemical cues to direct tissue regeneration, and enhance the efficacy of cancer immunotherapy.

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

" This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system design with the ability to carry out a significant independent project. This course was offered as part of the Singapore-MIT Alliance (SMA) program as course number SMA 5304."

This course will cover the basic concepts of clinical psychology -- the study of diagnosing, treating, and understanding abnormal and maladaptive behaviors. Much of the information in this course is based on the Diagnostic Statistical Manual IV-TR (DSM), which is the industry standard for both clinical psychologists and psychiatrists. Few issues in the field have hard-and-fast answers. As such, rather than providing you with step-by-step directions, this course has been designed to assist you in making educated decisions when diagnosing and treating a mental disease. Upon successful completion of this course, students will be able to: Describe the historical context of the emergence of clinical psychology; Demonstrate an awareness of the differences between mental health professionals in the broad field of clinical psychology; Identify the subspecialty areas within clinical psychology (i.e., community psychology, health psychology, and neuropsychology); Define the main tasks of the clinical psychologist and explain how the contributions of this subspecialty fit into or relate to the broader field of psychology; Define the criteria for what is considered 'abnormal' versus 'normal' and explain how these definitions fit into the notion that psychopathology exists on a continuum; Compare/contrast the different types of psychotherapy treatments; Discuss the ethical considerations related to the practice of psychotherapy; List the main diagnostic features of a variety of mental disorders (i.e., mood disorders, schizophrenia, etc.); Identify the potential factors that may contribute to the instigation and persistence of mental illness for individuals across the lifespan (i.e., children, adults, and older adults). (Psychology 205)

A diagnostic test is an objective method of deciding whether an animal has a disease, or not. Decisions made following diagnostic testing are usually dichotomous e.g. treat or do not treat the animal, therefore diagnostic tests are usually interpreted as dichotomous outcomes (diseased or non-diseased). In this case, if a diagnostic test is measuring a continuous outcome e.g. antibody titre then a cut-off for classifying animal’s as positive or negative must be selected. The figure below shows that whereever the cut-off is selected there is usually some overlap between results i.e. some diseased animals will have the same value as non-diseased animals and resulting in some false-positive and false-negative results.

Abnormal Psychology is an Open Education Resource written by Alexis Bridley, Ph.D. and Lee W. Daffin Jr., Ph.D. through Washington State University. The book tackles the difficult topic of mental disorders in 15 modules. This journey starts by discussing what abnormal behavior is by attempting to understand what normal behavior is. Models of abnormal psychology and clinical assessment, diagnosis, and treatment are then discussed. With these three modules completed, the authors next explore several classes of mental disorders in 5 blocks. Block 1 covers mood, trauma and stressor related, and dissociative disorders. Block 2 covers anxiety, somatic symptom, and obsessive-compulsive disorders. Block 3 covers eating and substance-related and addictive disorders. Block 4 tackles schizophrenia spectrum and personality disorders. Finally, Block 5 investigates neurocognitive disorders and then ends with a discussion of contemporary issues in psychopathology. Disorders are covered by discussing their clinical presentation and DSM Criteria, epidemiology, comorbidity, etiology, and treatment options.

Introduces representations, techniques, and architectures used to build applied systems and to account for intelligence from a computational point of view. Applications of rule chaining, heuristic search, constraint propagation, constrained search, inheritance, and other problem-solving paradigms. Applications of identification trees, neural nets, genetic algorithms, and other learning paradigms. Speculations on the contributions of human vision and language systems to human intelligence.

Neural structures and mechanisms mediating the detection, localization, and recognition of sounds. Discussion of how acoustic signals are coded by auditory neurons, the impact of these codes on behavorial performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants, and auditory scene analysis.

Subject provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include: general mechanisms of disease (inflammation, infection, immune injury, host response to foreign materials, transplantation, genetic disorders and neoplasia); pathology of lipids, enzymes, and molecular transporters; pathology of major organ systems; and review of diagnostic tools from invasive surgical pathology to non-invasive techniques such as optical spectroscopy, functional imaging, and molecular markers of disease. The objectives of this subject are achieved by a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology.

Psychology is designed to meet scope and sequence requirements for the single-semester introduction to psychology course. The book offers a comprehensive treatment of core concepts, grounded in both classic studies and current and emerging research. The text also includes coverage of the DSM-5 in examinations of psychological disorders. Psychology incorporates discussions that reflect the diversity within the discipline, as well as the diversity of cultures and communities across the globe.Senior Contributing AuthorsRose M. Spielman, Formerly of Quinnipiac UniversityContributing AuthorsKathryn Dumper, Bainbridge State CollegeWilliam Jenkins, Mercer UniversityArlene Lacombe, Saint Joseph's UniversityMarilyn Lovett, Livingstone CollegeMarion Perlmutter, University of Michigan

By the end of this section, you will be able to:

Explain why classification systems are necessary in the study of psychopathology
Describe the basic features of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
Discuss changes in the DSM over time, including criticisms of the current edition
Identify which disorders are generally the most common