Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts.

This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire‰ŰŞs disease, tuberculosis, Helicobacter pylori, and plague.

This is a seminar based on research literature. Papers covered are selected to illustrate important problems and approaches in the field of computational and systems biology, and provide students a framework from which to evaluate new developments. The MIT Initiative in Computational and Systems Biology (CSBi) is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D. program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology.

" In 2004, the Ansari X PRIZE for suborbital spaceflight captured the public's imagination and revolutionized an industry, leveraging a $10M prize purse into over $100M in innovation. Building from that success, the X PRIZE Foundation is now developing new prizes to focus innovation around "Grand Challenge" themes, including genomics, energy, healthcare, and education. This course will examine the intersection of incentives and innovation, drawing on economic models, historic examples, and recent experience of the X PRIZE Foundation to help develop a future prize in Energy Storage Technologies."